Journal article

Authors list: Babkina, Valeriia; Haiduk, Yana; Kurtash, Yuliia; Zorn, Holger; Zhuk, Tatyana

Publication year: 2024

Pages: 44-48

Journal: Journal of Biotechnology

Volume number: 387

ISSN: 0168-1656

eISSN: 1873-4863

Open access status: Hybrid

DOI Link: https://doi.org/10.1016/j.jbiotec.2024.03.015

Publisher: Elsevier

Abstract: 
The biocatalytic aerobic "in-water" reduction of anthranilic acid to 2-aminobenzaldehyde by growing cultures of the basidiomycetous white-rot fungus Bjerkandera adusta has been studied. The high specific activity of Bjerkandera adusta towards the carboxylic group of anthranilic acid that allows avoiding the formation of the corresponding alcohol has been demonstrated using different substrate concentrations. The presence of ethanol as co-solvent allows increasing the yield of target product. In contrast to chemical reducing agents that usually yield 2-aminobenzyl alcohol, an overreduction of anthranilic acid is completely suppressed by the fungus and gives the target flavor compound in satisfactory preparative yields. It was shown that the activity of Bjerkandera adusta towards anthranilic acid does not apply to its m- and p-isomers.

Harvard Citation style: Babkina, V., Haiduk, Y., Kurtash, Y., Zorn, H. and Zhuk, T. (2024) Reduction of anthranilic acid to 2-aminobenzaldehyde by the white-rot fungus Bjerkandera adusta DSMZ 4708, Journal of Biotechnology, 387, pp. 44-48. https://doi.org/10.1016/j.jbiotec.2024.03.015

APA Citation style: Babkina, V., Haiduk, Y., Kurtash, Y., Zorn, H., & Zhuk, T. (2024). Reduction of anthranilic acid to 2-aminobenzaldehyde by the white-rot fungus Bjerkandera adusta DSMZ 4708. Journal of Biotechnology. 387, 44-48. https://doi.org/10.1016/j.jbiotec.2024.03.015