Journal article

Authors list: Ringseis, Robert; Keller, Janine; Eder, Klaus

Publication year: 2018

Pages: 1686-1719

Journal: Journal of Animal Physiology and Animal Nutrition

Volume number: 102

Issue number: 6

ISSN: 0931-2439

eISSN: 1439-0396

Open access status: Bronze

DOI Link: https://doi.org/10.1111/jpn.12959

Publisher: Wiley

Abstract: 
A great number of studies have investigated the potential of L-carnitine as feed additive to improve performance of different monogastric and ruminant livestock species, with, however, discrepant outcomes. In order to understand the reasons for these discrepant outcomes, it is important to consider the determinants of L-carnitine status and how L-carnitine status is regulated in the animal's body. While it is a long-known fact that L-carnitine is endogenously biosynthesized in certain tissues, it was only recently recognized that critical determinants of L-carnitine status, such as intestinal L-carnitine absorption, tissue L-carnitine uptake, endogenous L-carnitine synthesis and renal L-carnitine reabsorption, are regulated by specific nutrient sensing nuclear receptors. This review aims to give a more in-depth understanding of the basic mechanisms of the regulation of L-carnitine status in monogastrics taking into account the most recent evidence on nutrient sensing nuclear receptors and evaluates the efficacy of L-carnitine as feed additive in monogastric livestock by providing an up-to-date overview about studies with L-carnitine supplementation in pigs and poultry.

Harvard Citation style: Ringseis, R., Keller, J. and Eder, K. (2018) Basic mechanisms of the regulation of L-carnitine status in monogastrics and efficacy of L-carnitine as a feed additive in pigs and poultry, Journal of Animal Physiology and Animal Nutrition, 102(6), pp. 1686-1719. https://doi.org/10.1111/jpn.12959

APA Citation style: Ringseis, R., Keller, J., & Eder, K. (2018). Basic mechanisms of the regulation of L-carnitine status in monogastrics and efficacy of L-carnitine as a feed additive in pigs and poultry. Journal of Animal Physiology and Animal Nutrition. 102(6), 1686-1719. https://doi.org/10.1111/jpn.12959