Journal article

Authors list: Zorn, H; Schüler, M; Berger, RG

Publication year: 2003

Pages: 341-347

Journal: Biocatalysis and Biotransformation

Volume number: 21

Issue number: 6

ISSN: 1024-2422

DOI Link: https://doi.org/10.1080/10242420310001630173

Publisher: Taylor and Francis Group

Abstract: 
Enzyme extracts of the wild type yeast Zygosaccharomyces bisporus were applied for the pyruvate decarboxylase catalysed condensation of pyruvate and ( R )-(+)-and ( S )-(-)-perillyl aldehyde, (+/-)-citronellal, neral, geranial or ( R )-(-)-myrtenal to form novel alpha-hydroxy ketones. Best yields were obtained when the transformation medium contained 25% (v/v) of the cosolvent N,N-dimethylformamide. Conversion of ( R )-(+)-perillyl aldehyde to (1 R )-1-hydroxy-1-[(4' R )-4'-isopropenyl-1-cyclohexen-1-yl]-2-propanone proceeded highly stereospecifically (>99% de), whereas the stereoselectivity was somewhat less in the transformation of ( S )-(-)-perillyl aldehyde (58% de) and ( R )-(-)-myrtenal (92% de). All of the new compounds imparted characteristic odour impressions as determined by means of GC-olfactometry.

Harvard Citation style: Zorn, H., Schüler, M. and Berger, R. (2003) Pyruvate decarboxylase catalysed formation of terpenoid alpha-hydroxy ketones, Biocatalysis and Biotransformation, 21(6), pp. 341-347. https://doi.org/10.1080/10242420310001630173

APA Citation style: Zorn, H., Schüler, M., & Berger, R. (2003). Pyruvate decarboxylase catalysed formation of terpenoid alpha-hydroxy ketones. Biocatalysis and Biotransformation. 21(6), 341-347. https://doi.org/10.1080/10242420310001630173