One-Pot Synthesis of Phthalazines and Pyridazino-aromatics: A Novel Strategy for Substituted Naphthalenes - Research portal of Justus Liebig University Giessen:

Journal article

One-Pot Synthesis of Phthalazines and Pyridazino-aromatics: A Novel Strategy for Substituted Naphthalenes

Authors list: Kessler, SN; Wegner, HA

Publication year: 2012

Pages: 3268-3271

Journal: Organic Letters

Volume number: 14

Issue number: 13

ISSN: 1523-7060

DOI Link: https://doi.org/10.1021/ol301167q

Publisher: American Chemical Society

Abstract:
A new one-pot strategy for the synthesis of phthalazines and pyridazino-aromatics starting from aromatic aldehydes has been developed. A variety of substituents ranging from electron withdrawing to donating is tolerated furnishing the desired 1,2-diazine in good to excellent yields. The products have been applied to the bidentate Lewis acid catalyzed inverse electron-demand Diels-Alder (IEDDA) reaction opening a novel two-step entry into substituted naphthalenes, such as Naproxen.

Authors/Editors

- Uni.-Prof. Dr. Hermann Andreas Wegner

Citation Styles

Harvard Citation style: Kessler, S. and Wegner, H. (2012) One-Pot Synthesis of Phthalazines and Pyridazino-aromatics: A Novel Strategy for Substituted Naphthalenes, Organic Letters, 14(13), pp. 3268-3271. https://doi.org/10.1021/ol301167q

APA Citation style: Kessler, S., & Wegner, H. (2012). One-Pot Synthesis of Phthalazines and Pyridazino-aromatics: A Novel Strategy for Substituted Naphthalenes. Organic Letters. 14(13), 3268-3271. https://doi.org/10.1021/ol301167q