Journalartikel

Autorenliste: Lippert, KM; Hof, K; Gerbig, D; Ley, D; Hausmann, H; Guenther, S; Schreiner, PR

Jahr der Veröffentlichung: 2012

Seiten: 5919-5927

Zeitschrift: European Journal of Organic Chemistry

Bandnummer: 2012

Heftnummer: 30

DOI Link: https://doi.org/10.1002/ejoc.201200739

Verlag: Wiley

Abstract: 

We present evidence that the privileged use of the
3,5‐bis(trifluoromethyl)phenyl group in thiourea organocatalysis is due
to the involvement of the ortho‐CH bond in the binding event with
Lewis‐basic sites. We utilized a combination of low‐temperature IR
spectroscopy, 2D NMR spectroscopy, nano‐MS (ESI) investigations, as well
as density functional theory computations [M06/6‐31+G(d,p),
including solvent corrections as well as natural bond orbital and
atoms‐in‐molecules analyses] to support our conclusions that bear
implications for catalyst design.

Harvard-Zitierstil: Lippert, K., Hof, K., Gerbig, D., Ley, D., Hausmann, H., Guenther, S., et al. (2012) Hydrogen‐Bonding Thiourea Organocatalysts: The Privileged 3,5‐Bis(trifluoromethyl)phenyl Group, European Journal of Organic Chemistry, 2012(30), pp. 5919-5927. https://doi.org/10.1002/ejoc.201200739

APA-Zitierstil: Lippert, K., Hof, K., Gerbig, D., Ley, D., Hausmann, H., Guenther, S., & Schreiner, P. (2012). Hydrogen‐Bonding Thiourea Organocatalysts: The Privileged 3,5‐Bis(trifluoromethyl)phenyl Group. European Journal of Organic Chemistry. 2012(30), 5919-5927. https://doi.org/10.1002/ejoc.201200739