Journal article

Authors list: Raymondos, K; Martin, MU; Schmudlach, T; Baus, S; Weilbach, C; Welte, T; Krettek, C; Frink, M; Hildebrand, F

Publication year: 2012

Pages: 189-195

Journal: Injury

Volume number: 43

Issue number: 2

ISSN: 0020-1383

DOI Link: https://doi.org/10.1016/j.injury.2011.05.034

Publisher: Elsevier

Abstract: 
Alveolar IL-8 has been reported to early identify patients at-risk to develop ARDS. However, it remains unknown how alveolar IL-8 is related to pulmonary and systemic inflammation in patients predisposed for ARDS. We studied 24 patients 2-6 h after multiple trauma. Patients with IL-8 >200 pg/ml in bronchoalveolar lavage (BAL) were assigned to the group at high risk for ARDS (H, n = 8) and patients with BAL IL-8 <200 pg/ml to the group at low risk for ARDS (L, n = 16). ARDS developed within 24 h after trauma in 5 patients at high and at least after 1 week in 2 patients at low risk for ARDS (p = 0.003). High-risk patients had also increased BAL IL-6, TNF-alpha, IL-1 beta, IL-10 and IL-1ra levels (p < 0.05). BAL neutrophil counts did not differ between patient groups (H vs. L, 12% (3-73%) vs. 6% (2-32%), p = 0.1) but correlated significantly with BAL IL-8, IL-6 and IL-1ra. High-risk patients had increased plasma levels of pro-but not anti-inflammatory mediators. The enhanced alveolar and systemic inflammation associated with alveolar IL-8 release should be considered to identify high-risk patients for pulmonary complications after multiple trauma to adjust surgical and other treatment strategies to the individual risk profile. (C) 2011 Elsevier Ltd. All rights reserved.

Harvard Citation style: Raymondos, K., Martin, M., Schmudlach, T., Baus, S., Weilbach, C., Welte, T., et al. (2012) Early alveolar and systemic mediator release in patients at different risks for ARDS after multiple trauma, Injury, 43(2), pp. 189-195. https://doi.org/10.1016/j.injury.2011.05.034

APA Citation style: Raymondos, K., Martin, M., Schmudlach, T., Baus, S., Weilbach, C., Welte, T., Krettek, C., Frink, M., & Hildebrand, F. (2012). Early alveolar and systemic mediator release in patients at different risks for ARDS after multiple trauma. Injury. 43(2), 189-195. https://doi.org/10.1016/j.injury.2011.05.034