Journal article

Authors list: Boraschi, D; Italiani, P; Weil, S; Martin, MU

Publication year: 2018

Pages: 197-232

Journal: Immunological Reviews

Volume number: 281

Issue number: 1

ISSN: 0105-2896

DOI Link: https://doi.org/10.1111/imr.12606

Publisher: Wiley

Abstract: 
The extracellular forms of the IL-1 cytokines are active through binding to specific receptors on the surface of target cells. IL-1 ligands bind to the extracellular portion of their ligand-binding receptor chain. For signaling to take place, a non-binding accessory chain is recruited into a heterotrimeric complex. The intracellular approximation of the Toll-IL-1-receptor (TIR) domains of the 2 receptor chains is the event that initiates signaling. The family of IL-1 receptors (IL-1R) includes 10 structurally related members, and the distantly related soluble protein IL-18BP that acts as inhibitor of the cytokine IL-18. Over the years the receptors of the IL-1 family have been known with many different names, with significant confusion. Thus, we will use here a recently proposed unifying nomenclature. The family includes several ligand-binding chains (IL-1R1, IL-1R2, IL-1R4, IL-1R5, and IL-1R6), 2 types of accessory chains (IL-1R3, IL-1R7), molecules that act as inhibitors of signaling (IL-1R2, IL-1R8, IL-18BP), and 2 orphan receptors (IL-1R9, IL-1R10). In this review, we will examine how the receptors of the IL-1 family regulate the inflammatory and anti-inflammatory functions of the IL-1 cytokines and are, more at large, involved in modulating defensive and pathological innate immunity and inflammation. Regulation of the IL-1/IL-1R system in the brain will be also described, as an example of the peculiarities of organ-specific modulation of inflammation.

Harvard Citation style: Boraschi, D., Italiani, P., Weil, S. and Martin, M. (2018) The family of the interleukin-1 receptors, Immunological Reviews, 281(1), pp. 197-232. https://doi.org/10.1111/imr.12606

APA Citation style: Boraschi, D., Italiani, P., Weil, S., & Martin, M. (2018). The family of the interleukin-1 receptors. Immunological Reviews. 281(1), 197-232. https://doi.org/10.1111/imr.12606