Journalartikel

Autorenliste: Kalinowski, J; Bathe, B; Bartels, D; Bischoff, N; Bott, M; Burkovski, A; Dusch, N; Eggeling, L; Eikmanns, BJ; Gaigalat, L; Goesmann, A; Hartmann, M; Huthmacher, K; Krämer, R; Linke, B; McHardy, AC; Meyer, F; Mockel, B; Pfefferle, W; Pühler, A; Rey, DA; Rückert, C; Rupp, O; Sahm, H; Wendisch, VF; Wiegrabe, I; Tauch, A

Jahr der Veröffentlichung: 2003

Seiten: 5-25

Zeitschrift: Journal of Biotechnology

Bandnummer: 104

Heftnummer: 1-3

ISSN: 0168-1656

eISSN: 1873-4863

DOI Link: https://doi.org/10.1016/S0168-1656(03)00154-8

Verlag: Elsevier

Abstract: 
The complete genomic sequence of Corynebacterium glutainicum ATCC 13032, well-known in industry for the production of amino acids, e.g. of L-glutamate and L-lysine was determined. The C glutamician genome was found to consist of a single circular chromosome comprising 3 282 708 base pairs. Several DNA regions of unusual composition were identified that were potentially acquired by horizontal gene transfer, e.g. a segment of DNA from C diphtheriae and a prophage-containing region. After automated and manual annotation, 3002 protein-coding genes have been identified, and to 2489 of these, functions were assigned by homologies to known proteins. These analyses confirm the taxonomic position of C glutamicum as related to Mycobacteria and show a broad metabolic diversity as expected for a bacterium living in the soil. As an example for biotechnological application the complete genome sequence was used to reconstruct the metabolic flow of carbon into a number of industrially important products derived from the amino acid L-aspartate.

Harvard-Zitierstil: Kalinowski, J., Bathe, B., Bartels, D., Bischoff, N., Bott, M., Burkovski, A., et al. (2003) The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins, Journal of Biotechnology, 104(1-3), pp. 5-25. https://doi.org/10.1016/S0168-1656(03)00154-8

APA-Zitierstil: Kalinowski, J., Bathe, B., Bartels, D., Bischoff, N., Bott, M., Burkovski, A., Dusch, N., Eggeling, L., Eikmanns, B., Gaigalat, L., Goesmann, A., Hartmann, M., Huthmacher, K., Krämer, R., Linke, B., McHardy, A., Meyer, F., Mockel, B., Pfefferle, W., ...Tauch, A. (2003). The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins. Journal of Biotechnology. 104(1-3), 5-25. https://doi.org/10.1016/S0168-1656(03)00154-8