Journal article

Authors list: Rother, D.; Gehron, J.; Brenck, F.; Hudel, H.; Boening, A.; Wenzel, F.

Publication year: 2024

Pages: 1-11

Journal: Clinical Hemorheology and Microcirculation: Blood Flow, Vessels and Imaging

Volume number: 87

Issue number: 1

ISSN: 1386-0291

eISSN: 1875-8622

Open access status: Bronze

DOI Link: https://doi.org/10.3233/CH-229105

Publisher: SAGE Publications

Abstract: 

INTRODUCTION: COVID-19 causes a considerable degradation of pulmonary function to the point of an acute respiratory distress syndrome (ARDS). Over the course of the disease the gas exchange capability of the lung can get impaired to such an extent that extracorporeal membrane oxygenation (ECMO) is needed as a life-saving intervention. In patients COVID-19 as well as ECMO may cause severe coagulopathies which manifest themselves in micro and macro thrombosis. Previous studies established D-dimers as a marker for critical thrombosis of the ECMO system while on admission increased D-dimers are associated with a higher mortality in COIVD-19 patients. It is therefore crucial to determine if COVID-19 poses an increased risk of early thrombosis of the vital ECMO system.

METHODS: 40 patients who required ECMO support were enrolled in a retrospective analysis and assigned into 2 groups. TheCOVID group consist of 20COVID-19 patients who requiredECMOsupport (n = 20), whereas 20ECMOpatients without COVID-19 were assigned to the control group. D-dimers, fibrinogen, antithrombin III (AT III), lactate dehydrogenase (LDH) and platelet count were analysed using locally weighted scatterplot smoothing and MANOVAs.

RESULTS: The analysis of both groups shows highly significant differences in the dynamics of hemostasis. The increase in D-dimers that is associated with thrombosis of the ECMO systems occurs in COVID-19 patients around 2 days earlier (p = 2,8115 10(-11)) while fibrinogen is consumed steadily. In the control group fibrinogen levels increase rapidly after ten days with a plateau phase of around five days (p = 1,407 10(-3)). Both groups experience a rapid increase in AT III after start of support by ECMO (p = 5,96 10(-15)). In the COVID group platelet count decreased from 210 giga/l to 130 giga/l within eight days, while in the same time span in the control group platelets decreased from 180 giga/l to 10(5) giga/l (p = 1,1 10(-15)). In both groups a marked increase in LDH beyond 5000 U/l occurs (p = 3,0865 10(-15)).

CONCLUSION: The early increase in D-dimers and decrease in fibrinogen suggests that COVID-19 patients bear an increased risk of early thrombosis of the ECMO system compared to other diseases treated with ECMO. Additionally, the control group shows signs of severe inflammation 10 days after the start of ECMO which were absent in COVID-19 patients.

Harvard Citation style: Rother, D., Gehron, J., Brenck, F., Hudel, H., Boening, A. and Wenzel, F. (2024) Influence of Covid-19 disease on hemostasis dynamics during extracorporeal membrane oxygenation (ECMO), Clinical Hemorheology and Microcirculation: Blood Flow, Vessels and Imaging, 87(1), pp. 1-11. https://doi.org/10.3233/CH-229105

APA Citation style: Rother, D., Gehron, J., Brenck, F., Hudel, H., Boening, A., & Wenzel, F. (2024). Influence of Covid-19 disease on hemostasis dynamics during extracorporeal membrane oxygenation (ECMO). Clinical Hemorheology and Microcirculation: Blood Flow, Vessels and Imaging. 87(1), 1-11. https://doi.org/10.3233/CH-229105