Journal article

Authors list: Mohiuddin, T. M.; Zhang, Chaoyu; Sheng, Wenjie; Al-Rawe, Marwah; Zeppernick, Felix; Meinhold-Heerlein, Ivo; Hussain, Ahmad Fawzi

Publication year: 2023

Journal: International Journal of Molecular Sciences

Volume number: 24

Issue number: 3

eISSN: 1422-0067

Open access status: Gold

DOI Link: https://doi.org/10.3390/ijms24032655

Publisher: MDPI

Abstract: 
Near infrared photoimmunotherapy (NIR-PIT) is a newly developed molecular targeted cancer treatment, which selectively kills cancer cells or immune-regulatory cells and induces therapeutic host immune responses by administrating a cancer targeting moiety conjugated with IRdye700. The local exposure to near-infrared (NIR) light causes a photo-induced ligand release reaction, which causes damage to the target cell, resulting in immunogenic cell death (ICD) with little or no side effect to the surrounding normal cells. Moreover, NIR-PIT can generate an immune response in distant metastases and inhibit further cancer attack by combing cancer cells targeting NIR-PIT and immune regulatory cells targeting NIR-PIT or other cancer treatment modalities. Several recent improvements in NIR-PIT have been explored such as catheter-driven NIR light delivery, real-time monitoring of cancer, and the development of new target molecule, leading to NIR-PIT being considered as a promising cancer therapy. In this review, we discuss the progress of NIR-PIT, their mechanism and design strategies for cancer treatment. Furthermore, the overall possible targeting molecules for NIR-PIT with their application for cancer treatment are briefly summarised.

Harvard Citation style: Mohiuddin, T., Zhang, C., Sheng, W., Al-Rawe, M., Zeppernick, F., Meinhold-Heerlein, I., et al. (2023) Near Infrared Photoimmunotherapy: A Review of Recent Progress and Their Target Molecules for Cancer Therapy, International Journal of Molecular Sciences, 24(3), Article 2655. https://doi.org/10.3390/ijms24032655

APA Citation style: Mohiuddin, T., Zhang, C., Sheng, W., Al-Rawe, M., Zeppernick, F., Meinhold-Heerlein, I., & Hussain, A. (2023). Near Infrared Photoimmunotherapy: A Review of Recent Progress and Their Target Molecules for Cancer Therapy. International Journal of Molecular Sciences. 24(3), Article 2655. https://doi.org/10.3390/ijms24032655