Journal article

Authors list: Bowl, Wadim; Raoof, Sinan; Lorenz, Birgit; Holve, Kerstin; Schweinfurth, Silke; Stieger, Knut; Andrassi-Darida, Monika

Publication year: 2019

Pages: 1614-1620

Journal: Investigative ophthalmology & visual science

Volume number: 60

Issue number: 5

ISSN: 0146-0404

eISSN: 1552-5783

Open access status: Gold

DOI Link: https://doi.org/10.1167/iovs.18-24892

Publisher: Association for Research in Vision and Ophthalmology

Abstract: 

PURPOSE. To correlate cone- and rod-mediated function with morphology of the macula in preterm-born children without and with spontaneously regressed retinopathy of prematurity (ROP).

METHODS. We performed spectral-domain optical coherence tomography (SD-OCT) single scans in the macular center of preterm-born children aged 6 to 12 years (mean +/- SD, 7.4 +/- 1.8) without ROP (noROP; n = 59) and with spontaneously regressed ROP (srROP; n = 34), documented with wide-angle digital imaging during routine screening for acute ROP, and compared the data from 14 age-matched term-born children. SD-OCT data were compared to functional cone- and rod-mediated results of scotopic and photopic chromatic pupillometry (cP) and two-color fundus-controlled perimetry (2C-FCP).

RESULTS. SD-OCT showed a shallowed foveal pit with significantly reduced outer nuclear layer to inner retinal layer ratio, indicating macular developmental arrest (MDA). MDA was present in 44% of the srROP and 27% of the noROP children. Pupil reaction to photopic red stimuli on blue background showed significantly lower values in all preterm-born children with MDA. In accordance, photopic light increment sensitivity (LIS) to red stimuli in the foveal center on the 2C-FCP was also significantly reduced in children with MDA. Under scotopic conditions, no significant differences were apparent in both pupil reaction with cP and LIS with 2C-FCP.

CONCLUSIONS. Both objective pupillary response to cone-mediated photopic red stimuli and subjective central cone-mediated results in fundus-controlled perimetry were reduced in preterm-born children with MDA. MDA was present in a significant number of patients with srROP, but also without ROP.

Harvard Citation style: Bowl, W., Raoof, S., Lorenz, B., Holve, K., Schweinfurth, S., Stieger, K., et al. (2019) Cone-Mediated Function Correlates to Altered Foveal Morphology in Preterm-Born Children at School Age, Investigative ophthalmology & visual science, 60(5), pp. 1614-1620. https://doi.org/10.1167/iovs.18-24892

APA Citation style: Bowl, W., Raoof, S., Lorenz, B., Holve, K., Schweinfurth, S., Stieger, K., & Andrassi-Darida, M. (2019). Cone-Mediated Function Correlates to Altered Foveal Morphology in Preterm-Born Children at School Age. Investigative ophthalmology & visual science. 60(5), 1614-1620. https://doi.org/10.1167/iovs.18-24892