Journal article

Authors list: Daher, Tamas; Tur, Mehmet Kemal; Brobeil, Alexander; Etschmann, Benjamin; Witte, Biruta; Engenhart-Cabillic, Rita; Krombach, Gabriele; Blau, Wolfgang; Grimminger, Friedrich; Seeger, Werner; Klussmann, Jens Peter; Braeuninger, Andreas; Gattenloehner, Stefan

Publication year: 2018

Pages: 1109-1119

Journal: Head and Neck

Volume number: 40

Issue number: 6

ISSN: 1043-3074

eISSN: 1097-0347

DOI Link: https://doi.org/10.1002/hed.25041

Publisher: Wiley

Abstract: 

BackgroundIn head and neck squamous cell carcinoma (HNSCC), the occurrence of concurrent lung malignancies poses a significant diagnostic challenge because metastatic HNSCC is difficult to discern from second primary lung squamous cell carcinoma (SCC). However, this differentiation is crucial because the recommended treatments for metastatic HNSCC and second primary lung SCC differ profoundly.

MethodsWe analyzed the origin of lung tumors in 32 patients with HNSCC using human papillomavirus (HPV) typing and targeted next generation sequencing of all coding exons of tumor protein 53 (TP53).

ResultsLung tumors were clearly identified as HNSCC metastases or second primary tumors in 29 patients, thus revealing that 16 patients had received incorrect diagnoses based on clinical and morphological data alone.

ConclusionThe HPV typing and mutation analysis of all TP53 coding exons is a valuable diagnostic tool in patients with HNSCC and concurrent lung SCC, which can help to ensure that patients receive the most suitable treatment.

Harvard Citation style: Daher, T., Tur, M., Brobeil, A., Etschmann, B., Witte, B., Engenhart-Cabillic, R., et al. (2018) Combined human papillomavirus typing and TP53 mutation analysis in distinguishing second primary tumors from lung metastases in patients with head and neck squamous cell carcinoma, Head and Neck, 40(6), pp. 1109-1119. https://doi.org/10.1002/hed.25041

APA Citation style: Daher, T., Tur, M., Brobeil, A., Etschmann, B., Witte, B., Engenhart-Cabillic, R., Krombach, G., Blau, W., Grimminger, F., Seeger, W., Klussmann, J., Braeuninger, A., & Gattenloehner, S. (2018). Combined human papillomavirus typing and TP53 mutation analysis in distinguishing second primary tumors from lung metastases in patients with head and neck squamous cell carcinoma. Head and Neck. 40(6), 1109-1119. https://doi.org/10.1002/hed.25041