Conference paper

Authors list: Bhushan, Sudhanshu; Schuppe, Hans-Christian; Tchatalbachev, Svetlin; Fijak, Monika; Weidner, Wolfgang; Chakraborty, Trinad; Meinhardt, Andreas

Publication year: 2009

Pages: 37-44

Journal: Molecular and Cellular Endocrinology

Volume number: 306

Issue number: 1-2

ISSN: 0303-7207

eISSN: 1872-8057

Open access status: Green

DOI Link: https://doi.org/10.1016/j.mce.2008.10.017

Conference: 15th European Workshop on Molecular and Cellular Endocrinology of the Testis

Publisher: Elsevier

Abstract: 
Infection and inflammation are relevant entities of male factor infertility. Bacterial infections are mostly the consequence of an ascending infection of the genito-urinary tract which can ultimately lead to epididymo-orchitis. Bacterial toxins and the innate immune responses directed against them may have a significant impact on male reproductive function. Toll-like receptors (TLRs) constitute the major family of pattern recognition receptors that play a pivotal role in innate immunity. In the testis, TLRs are not only found in immune cells such as macrophages and dendritic cells, but also in testicular somatic cells and to a lesser extent in germ cells. In this review we describe relevant bacterial pathogens found in testicular and male reproductive tract infection, new data on the localisation and potential functions of TLRs, recognition and response to bacteria with a special emphasis on uropathogenic Escherichia coli. Mechanisms by which uropathogenic E. coli subvert innate immune responses in the testis are discussed using information derived from animal model studies. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

Harvard Citation style: Bhushan, S., Schuppe, H., Tchatalbachev, S., Fijak, M., Weidner, W., Chakraborty, T., et al. (2009) Testicular innate immune defense against bacteria, Molecular and Cellular Endocrinology, 306(1-2), pp. 37-44. https://doi.org/10.1016/j.mce.2008.10.017

APA Citation style: Bhushan, S., Schuppe, H., Tchatalbachev, S., Fijak, M., Weidner, W., Chakraborty, T., & Meinhardt, A. (2009). Testicular innate immune defense against bacteria. Molecular and Cellular Endocrinology. 306(1-2), 37-44. https://doi.org/10.1016/j.mce.2008.10.017