Journal article

Authors list: ORLICKY, J; RUSCAK, M; RUSCAKOVA, D; HAGER, H

Publication year: 1979

Pages: 1551-155+

Journal: Journal of Neurochemistry

Volume number: 32

Issue number: 5

ISSN: 0022-3042

eISSN: 1471-4159

DOI Link: https://doi.org/10.1111/j.1471-4159.1979.tb11098.x

Publisher: Wiley

Abstract: 
Alanine aminotransferase EC 2.6.1.2 activity in subcellular fractions of rat brains was investigated during ontogenic development. The activity rose from the prenatal period until adulthood, the highest increase being observed during the period of morphological, metabolic and functional maturation of the brain. The rise of the total activity was due predominantly to a rise in the activity of the cytosolic enzyme; the activity of the mitochondrial enzyme did not change markedly during ontogeny. Cl- and elevated temperature (55.degree. C) inhibited the activity only of the mitochondrial enzyme. Raised temperature stimulated the activity of the cytosolic enzyme while Cl- did not influence its activity. Already present in the rat brain in prenatal period are 2-alanine aminotransferase isoenzymes. The cytosolic enzyme is presumed to be involved in the regulation of tissue glycolysis and alanine formation, while the mitochondrial enzyme plays a role in the amino nitrogen transport between mitochondria and cytosol.

Harvard Citation style: ORLICKY, J., RUSCAK, M., RUSCAKOVA, D. and HAGER, H. (1979) 2 FORMS OF ALANINE AMINOTRANSFERASE IN RAT-BRAIN DURING ONTOGENY, Journal of Neurochemistry, 32(5), pp. 1551-155+. https://doi.org/10.1111/j.1471-4159.1979.tb11098.x

APA Citation style: ORLICKY, J., RUSCAK, M., RUSCAKOVA, D., & HAGER, H. (1979). 2 FORMS OF ALANINE AMINOTRANSFERASE IN RAT-BRAIN DURING ONTOGENY. Journal of Neurochemistry. 32(5), 1551-155+. https://doi.org/10.1111/j.1471-4159.1979.tb11098.x