Journalartikel

Autorenliste: KLOCZEWIAK, M; WEGRZYNOWICZ, Z; MATTHIAS, FR; HEENE, DL; ZAJDEL, M

Jahr der Veröffentlichung: 1976

Seiten: 324-333

Zeitschrift: Thrombosis and Haemostasis

Bandnummer: 35

Heftnummer: 2

ISSN: 0340-6245

eISSN: 2567-689X

DOI Link: https://doi.org/10.1055/s-0038-1647925

Verlag: Thieme Publishing

Abstract: 
Treatment of fibrinogen [bovine] with maleic acid anhydride rendered fibrinogen unclottable depending on the degree of modification of the molecule. According to radioactive studies, the release of fibrinopeptides by thrombin or reptilase was undisturbed. The incoagulability was due to inhibition of the polymerization process of fibrin monomers derived from modified fibrinogen, mainly caused by the increase of electronegative charges upon the fibrinogen molecule. According to disc electrophoresis modified fibrinogen failed to produce fragments D and E following plasmic digestion, but may be degraded to high MW products. Modified fibrinogen revealed some similarities to abnormal fibrinogens in congenital dysfibrinogenemia with regard to its functional properties.

Harvard-Zitierstil: KLOCZEWIAK, M., WEGRZYNOWICZ, Z., MATTHIAS, F., HEENE, D. and ZAJDEL, M. (1976) STUDIES ON CHEMICALLY MODIFIED FIBRINOGEN, Thrombosis and Haemostasis, 35(2), pp. 324-333. https://doi.org/10.1055/s-0038-1647925

APA-Zitierstil: KLOCZEWIAK, M., WEGRZYNOWICZ, Z., MATTHIAS, F., HEENE, D., & ZAJDEL, M. (1976). STUDIES ON CHEMICALLY MODIFIED FIBRINOGEN. Thrombosis and Haemostasis. 35(2), 324-333. https://doi.org/10.1055/s-0038-1647925