Journal article

Authors list: López, JL; Lozano, MJ; Lagares, A; Fabre, ML; Draghi, WO; Del Papa, MF; Pistorio, M; Becker, A; Wibberg, D; Schlüter, A; Pühler, A; Blom, J; Goesmann, A; Lagares, A

Publication year: 2019

Pages: e00505-19-

Journal: mBio

Volume number: 10

Issue number: 3

Open access status: Gold

DOI Link: https://doi.org/10.1128/mBio.00505-19

Publisher: American Society for Microbiology

Abstract: 
Bacterial genomes usually include many thousands of genes which are expressed with diverse spatial-temporal patterns and intensities. A well-known evidence is that highly expressed genes, such as the ribosomal and other translation-related proteins (RTRPs), have accommodated their codon usage to optimize translation efficiency and accuracy. Using a bioinformatic approach, we identify core-genes sets with different ancestries, and demonstrate that selection processes that optimize codon usage are not restricted to RTRPs but extended at a genome-wide scale. Such findings highlight, for the first time, a previously undiscovered adaptation strategy associated with the chromosomal-core information. Contrasted with the translationally more adapted genes, singletons (i.e., exclusive genes, including those of the plasmidome) appear as the gene pool with the less-ameliorated codon usage in the lineage. A comprehensive summary describing the inter- and intra-replicon heterogeneity of codon usages in a complex prokaryote genome is presented.

Harvard Citation style: López, J., Lozano, M., Lagares, A., Fabre, M., Draghi, W., Del Papa, M., et al. (2019) Codon Usage Heterogeneity in the Multipartite Prokaryote Genome: Selection-Based Coding Bias Associated with Gene Location, Expression Level, and Ancestry., mBio, 10(3), p. e00505-19. https://doi.org/10.1128/mBio.00505-19

APA Citation style: López, J., Lozano, M., Lagares, A., Fabre, M., Draghi, W., Del Papa, M., Pistorio, M., Becker, A., Wibberg, D., Schlüter, A., Pühler, A., Blom, J., Goesmann, A., & Lagares, A. (2019). Codon Usage Heterogeneity in the Multipartite Prokaryote Genome: Selection-Based Coding Bias Associated with Gene Location, Expression Level, and Ancestry.. mBio. 10(3), e00505-19. https://doi.org/10.1128/mBio.00505-19