Zinc deficiency and concentrations of lipids in plasma and lipoproteins of rats force-fed a diet with linseed oil - Research portal of Justus Liebig University Giessen:

Journal article

Zinc deficiency and concentrations of lipids in plasma and lipoproteins of rats force-fed a diet with linseed oil

Authors list: Eder, K; Kirchgeßner, K

Publication year: 1994

Pages: 92-95

Journal: Trace Elements and Electrolytes

Volume number: 11

Issue number: 2

ISSN: 0174-7371

Publisher: Dustri-Verlag

Abstract:
The present study investigated the effect of zinc deficiency on concentrations of cholesterol, triglycerides and phospholipids in plasma and lipoproteins in rats force-fed a diet containing linseed oil. Male Sprague Dawley rats were either fed a control diet (25 mg Zn/kg) or a zinc deficient diet (0.8 mg Zn/kg) by gastric tube (11.6 g per day) for 10 days. Lipoproteins of plasma were separated by ultracentrifugation and lipids in plasma and lipoprotein fractions were analyzed enzymatically. Zinc deficient rats gained hyperlipidemia which was characterized by elevated levels of lipids in all kinds of lipoproteins, most pronounced in LDL fraction. In zinc deficient rats, there was an elevation of concentrations of cholesterol (by 96%) and phospholipids (by 132%) in HDL fraction, an elevation of concentrations of cholesterol (by 20%), triglycerides (by 42%) and phosphohpids (by 42%) in LDL fraction, as well as an elevation of concentrations of cholesterol (by 464%), triglycerides (by 59%) and phospholipids (by 77%) in VLDL fraction. Zinc deficient rats fed linseed oil diet had also elevated concentrations of total protein, albumin, urea and calcium as well as activity of ALAT in plasma. The results of the present study agree with those of a recent study in which rats were force-fed a zinc deficient diet with fish oil suggesting that zinc deficiency causes characteristic changes in lipid metabolism of rats force-fed a diet containing oils rich in n-3 fatty acids.

Authors/Editors

- Uni.-Prof. Dr. Klaus Josef Eder

Citation Styles

Harvard Citation style: Eder, K. and Kirchgeßner, K. (1994) Zinc deficiency and concentrations of lipids in plasma and lipoproteins of rats force-fed a diet with linseed oil, Trace Elements and Electrolytes, 11(2), pp. 92-95

APA Citation style: Eder, K., & Kirchgeßner, K. (1994). Zinc deficiency and concentrations of lipids in plasma and lipoproteins of rats force-fed a diet with linseed oil. Trace Elements and Electrolytes. 11(2), 92-95.