Journal article

Authors list: Sturm, C; Wagner, AE

Publication year: 2017

Pages: 1890-

Journal: International Journal of Molecular Sciences

Volume number: 18

Issue number: 9

ISSN: 1422-0067

DOI Link: https://doi.org/10.3390/ijms18091890

Publisher: MDPI

Abstract: 
A high consumption of vegetables belonging to the Brassicaceae family has been related to a lower incidence of chronic diseases including different kinds of cancer. These beneficial effects of, e.g., broccoli, cabbage or rocket (arugula) intake have been mainly dedicated to the sulfur-containing glucosinolates (GLSs)secondary plant compounds nearly exclusively present in Brassicaceaeand in particular to their bioactive breakdown products including isothiocyanates (ITCs). Overall, the current literature indicate that selected Brassica-derived ITCs exhibit health-promoting effects in vitro, as well as in laboratory mice in vivo. Some studies suggest anti-carcinogenic and anti-inflammatory properties for ITCs which may be communicated through an activation of the redox-sensitive transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) that controls the expression of antioxidant and phase II enzymes. Furthermore, it has been shown that ITCs are able to significantly ameliorate a severe inflammatory phenotype in colitic mice in vivo. As there are studies available suggesting an epigenetic mode of action for Brassica-derived phytochemicals, the conduction of further studies would be recommendable to investigate if the beneficial effects of these compounds also persist during an irregular consumption pattern.

Harvard Citation style: Sturm, C. and Wagner, A. (2017) Brassica-Derived Plant Bioactives as Modulators of Chemopreventive and Inflammatory Signaling Pathways, International Journal of Molecular Sciences, 18(9), p. 1890. https://doi.org/10.3390/ijms18091890

APA Citation style: Sturm, C., & Wagner, A. (2017). Brassica-Derived Plant Bioactives as Modulators of Chemopreventive and Inflammatory Signaling Pathways. International Journal of Molecular Sciences. 18(9), 1890. https://doi.org/10.3390/ijms18091890