Dietary Resveratrol Does Not Affect Life Span, Body Composition, Stress Response, and Longevity-Related Gene Expression in Drosophila melanogaster - Research portal of Justus Liebig University Giessen:

Journal article

Dietary Resveratrol Does Not Affect Life Span, Body Composition, Stress Response, and Longevity-Related Gene Expression in Drosophila melanogaster

Authors list: Staats, S; Wagner, AE; Kowalewski, B; Rieck, FT; Soukup, ST; Kulling, SE; Rimbach, G

Publication year: 2018

Pages: 223-

Journal: International Journal of Molecular Sciences

Volume number: 19

Issue number: 1

ISSN: 1422-0067

DOI Link: https://doi.org/10.3390/ijms19010223

Publisher: MDPI

Abstract:
In this study, we tested the effect of the stilbene resveratrol on life span, body composition, locomotor activity, stress response, and the expression of genes encoding proteins centrally involved in ageing pathways in the model organism Drosophila melanogaster. Male and female w(1118) D. melanogaster were fed diets based on sucrose, corn meal, and yeast. Flies either received a control diet or a diet supplemented with 500 mu mol/L resveratrol. Dietary resveratrol did not affect mean, median, and maximal life span of male and female flies. Furthermore, body composition remained largely unchanged following the resveratrol supplementation. Locomotor activity, as determined by the climbing index, was not significantly different between control and resveratrol-supplemented flies. Resveratrol-fed flies did not exhibit an improved stress response towards hydrogen peroxide as compared to controls. Resveratrol did not change mRNA steady levels of antioxidant (catalase, glutathione-S-transferase, NADH dehydrogenase, glutathione peroxidase, superoxide dismutase 2) and longevity-related genes, including sirtuin 2, spargel, and I'm Not Dead Yet. Collectively, present data suggest that resveratrol does not affect life span, body composition, locomotor activity, stress response, and longevity-associated gene expression in w(1118) D. melanogaster.

Authors/Editors

- Uni.-Prof. Dr. Anika Eva Wagner

Citation Styles

Harvard Citation style: Staats, S., Wagner, A., Kowalewski, B., Rieck, F., Soukup, S., Kulling, S., et al. (2018) Dietary Resveratrol Does Not Affect Life Span, Body Composition, Stress Response, and Longevity-Related Gene Expression in Drosophila melanogaster, International Journal of Molecular Sciences, 19(1), p. 223. https://doi.org/10.3390/ijms19010223

APA Citation style: Staats, S., Wagner, A., Kowalewski, B., Rieck, F., Soukup, S., Kulling, S., & Rimbach, G. (2018). Dietary Resveratrol Does Not Affect Life Span, Body Composition, Stress Response, and Longevity-Related Gene Expression in Drosophila melanogaster. International Journal of Molecular Sciences. 19(1), 223. https://doi.org/10.3390/ijms19010223