Journal article

Authors list: Ruhl, J; Ahles, S; Strauss, MA; Leonhardt, CM; Wegner, HA

Publication year: 2021

Pages: 2089-2093

Journal: Organic Letters

Volume number: 23

Issue number: 6

ISSN: 1523-7060

eISSN: 1523-7052

DOI Link: https://doi.org/10.1021/acs.orglett.1c00249

Publisher: American Chemical Society

Abstract: 
The combination of a Lewis acid-catalyzed inverse electron-demand Diels-Alder (IEDDA) reaction with a photoinduced ring-opening (PIRO) reaction in a domino process has been established as an efficient synthetic method to access medium-sized carbocycles. From readily available electron-rich and electron-poor phthalazines and enamines, respectively, as starting materials, various 9- and 11-membered carbocycles were prepared. This versatile transition-metal-free tool will be valuable for broadening the structural space in biologically active compounds and functional materials.

Harvard Citation style: Ruhl, J., Ahles, S., Strauss, M., Leonhardt, C. and Wegner, H. (2021) Synthesis of Medium-Sized Carbocycles via a Bidentate Lewis Acid-Catalyzed Inverse Electron-Demand Diels-Alder Reaction Followed by Photoinduced Ring-Opening, Organic Letters, 23(6), pp. 2089-2093. https://doi.org/10.1021/acs.orglett.1c00249

APA Citation style: Ruhl, J., Ahles, S., Strauss, M., Leonhardt, C., & Wegner, H. (2021). Synthesis of Medium-Sized Carbocycles via a Bidentate Lewis Acid-Catalyzed Inverse Electron-Demand Diels-Alder Reaction Followed by Photoinduced Ring-Opening. Organic Letters. 23(6), 2089-2093. https://doi.org/10.1021/acs.orglett.1c00249