A Facile and Inexpensive Way to Synthesize N-trifluoromethyl Compounds - Forschungsportal der Justus-Liebig-Universität Gießen:

Journal article

A Facile and Inexpensive Way to Synthesize N-trifluoromethyl Compounds

Authors list: Schaub, S; Becker, J; Schindler, S

Publication year: 2022

Journal: ChemistrySelect

Volume number: 7

Issue number: 23

ISSN: 2365-6549

Open access status: Hybrid

DOI Link: https://doi.org/10.1002/slct.202201803

Publisher: Wiley

Abstract:
A facile way to introduce CF3 groups on a large variety of secondary amines has been developed, avoiding expensive and hazardous reagents. The advantage of the method could be demonstrated by obtaining crystalline tert-butyl 4-(trifluoromethyl)piperazine-1-carboxylate, a compound that previously only had been obtained as an oil. A major problem is the extreme sensitivity of these compounds towards moisture.

Authors/Editors

- Uni.-Prof. Dr. Siegfried Adolf Schindler

Citation Styles

Harvard Citation style: Schaub, S., Becker, J. and Schindler, S. (2022) A Facile and Inexpensive Way to Synthesize N-trifluoromethyl Compounds, ChemistrySelect, 7(23), Article e202201803. https://doi.org/10.1002/slct.202201803

APA Citation style: Schaub, S., Becker, J., & Schindler, S. (2022). A Facile and Inexpensive Way to Synthesize N-trifluoromethyl Compounds. ChemistrySelect. 7(23), Article e202201803. https://doi.org/10.1002/slct.202201803

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