Journal article

Authors list: Reutzel, M; Grewal, R; Joppe, A; Eckert, GP

Publication year: 2022

Journal: Frontiers in Aging Neuroscience

Volume number: 14

ISSN: 1663-4365

Open access status: Gold

DOI Link: https://doi.org/10.3389/fnagi.2022.875989

Publisher: Frontiers Media

Abstract: 
Aging is the main risk factor for sporadic Alzheimer's disease (AD), which is characterized by the cerebral deposition of beta-amyloid peptides (A beta) and cognitive decline. Mitochondrial dysfunction is also characteristic of the disease and represents a hallmark of both, aging and neurodegeneration. We longitudinally followed A beta levels, cognition, and mitochondrial function in the same cohort of Thy1-APP(751)SL mice representing a murine model of AD. In the course of time, changes were most prominent at an age of 13 months including the latency time in the passive avoidance test, the activity of complexes I and IV of the mitochondrial respiration chain, and expression of genes related to mitochondrial biogenesis and synaptic plasticity including Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1-alpha), CAMP responsive element binding protein 1 (CREB1), and Synaptophysin 1 (SYP1). These changes occurred in parallel with massively increasing cerebral A beta levels. Other parameters were changed in younger mice including the alteration rate in the Y-maze test and the nesting score when A beta levels were not changed yet. The results are consistent in the cohort described. However, previous, non-longitudinal studies reported divergent time points for the occurrence of the parameters studied. These findings are discussed in light of the current results.

Harvard Citation style: Reutzel, M., Grewal, R., Joppe, A. and Eckert, G. (2022) Age-Dependent Alterations of Cognition, Mitochondrial Function, and Beta-Amyloid Deposition in a Murine Model of Alzheimer’s Disease—A Longitudinal Study, Frontiers in Aging Neuroscience, 14, Article 875989. https://doi.org/10.3389/fnagi.2022.875989

APA Citation style: Reutzel, M., Grewal, R., Joppe, A., & Eckert, G. (2022). Age-Dependent Alterations of Cognition, Mitochondrial Function, and Beta-Amyloid Deposition in a Murine Model of Alzheimer’s Disease—A Longitudinal Study. Frontiers in Aging Neuroscience. 14, Article 875989. https://doi.org/10.3389/fnagi.2022.875989