Journalartikel

Autorenliste: Hagmaier, K; Jennings, S; Buse, J; Weber, F; Kochs, G

Jahr der Veröffentlichung: 2003

Seiten: 2747-2752

Zeitschrift: Journal of Virology

Bandnummer: 77

Heftnummer: 4

ISSN: 0022-538X

DOI Link: https://doi.org/10.1128/JVI.77.4.2747-2752.2003

Verlag: American Society for Microbiology

Abstract: 

Thogoto virus (THOV) is a tick-transmitted orthomyxovirus with a genome of six negative-stranded RNA segments. The sixth segment encodes two different transcripts: a spliced transcript that is translated into the matrix protein (M) and an unspliced transcript. Here, we report that the unspliced transcript encodes an elongated form of M named ML. A THOV isolate deficient in ML expression was an efficient interferon inducer, whereas ML-expressing wild-type strains were poor interferon inducers. These results were confirmed with recombinant THOVs rescued from cDNAs. Expression of ML efficiently suppressed activation of the beta interferon promoter by double-stranded RNA. These results indicate that ML is an accessory protein that functions as a potent interferon antagonist by blocking transcriptional activation of alpha/beta interferons.

Harvard-Zitierstil: Hagmaier, K., Jennings, S., Buse, J., Weber, F. and Kochs, G. (2003) Novel Gene Product of Thogoto Virus Segment 6 Codes for an Interferon Antagonist, Journal of Virology, 77(4), pp. 2747-2752. https://doi.org/10.1128/JVI.77.4.2747-2752.2003

APA-Zitierstil: Hagmaier, K., Jennings, S., Buse, J., Weber, F., & Kochs, G. (2003). Novel Gene Product of Thogoto Virus Segment 6 Codes for an Interferon Antagonist. Journal of Virology. 77(4), 2747-2752. https://doi.org/10.1128/JVI.77.4.2747-2752.2003