Journal article

Authors list: Spiegel, M; Pichlmair, A; Mühlberger, E; Haller, O; Weber, F

Publication year: 2004

Pages: 211-213

Journal: Journal of Clinical Virology

Volume number: 30

Issue number: 3

ISSN: 1386-6532

eISSN: 1873-5967

DOI Link: https://doi.org/10.1016/j.jcv.2003.11.013

Publisher: Elsevier

Abstract: 

Severe acute respiratory syndrome (SARS) is caused by a novel coronavirus termed SARS-CoV No antiviral treatment has been established so far. Interferons are cytokines which induce the synthesis of several antivirally active proteins in the cell. In this study, we demonstrated that multiplication of SARS-CoV in cell culture can be strongly inhibited by pretreatment with interferon-beta. Interferon-alpha and interferon-gamma, by contrast, were less effective. The human MxA protein is one of the most prominent proteins induced by interferon-beta. Nevertheless, no interference with SARS-CoV replication was observed in Vero cells stably expressing MxA. Therefore, other interferon-induced proteins must be responsible for the strong inhibitory effect of interferon-beta against SARS-CoV.

Harvard Citation style: Spiegel, M., Pichlmair, A., Mühlberger, E., Haller, O. and Weber, F. (2004) The antiviral effect of interferon-beta against SARS-Coronavirus is not mediated by MxA protein, Journal of Clinical Virology, 30(3), pp. 211-213. https://doi.org/10.1016/j.jcv.2003.11.013

APA Citation style: Spiegel, M., Pichlmair, A., Mühlberger, E., Haller, O., & Weber, F. (2004). The antiviral effect of interferon-beta against SARS-Coronavirus is not mediated by MxA protein. Journal of Clinical Virology. 30(3), 211-213. https://doi.org/10.1016/j.jcv.2003.11.013