Activation of Innate Defense against a Paramyxovirus Is Mediated by RIG-I and TLR7 and TLR8 in a Cell-Type-Specific Manner - Forschungsportal der Justus-Liebig-Universität Gießen:

Journal article

Activation of Innate Defense against a Paramyxovirus Is Mediated by RIG-I and TLR7 and TLR8 in a Cell-Type-Specific Manner

Authors list: Melchjorsen, J; Jensen, SB; Malmgaard, L; Rasmussen, SB; Weber, F; Bowie, AG; Matikainen, S; Paludan, SR

Publication year: 2005

Pages: 12944-12951

Journal: Journal of Virology

Volume number: 79

Issue number: 20

ISSN: 0022-538X

eISSN: 1098-5514

DOI Link: https://doi.org/10.1128/JVI.79.20.12944-12951.2005

Publisher: American Society for Microbiology

Abstract:
Recognition of pathogens by the innate immune system is mediated by pattern recognition receptors (PRRs), which recognize specific molecular structures of the infectious agents and subsequently trigger expression of genes involved in host defense. Toll-like receptors (TLRs) represent a well-characterized class of membrane-bound PRRs, and the RNA helicase retinoic acid inducible gene I (RIG-I) has recently been described as a novel cytoplasmic PRR recognizing double-stranded RNA (dsRNA). Here we show that activation of signal transduction and induction of cytokine expression by the paramyxovirus Sendai virus is dependent on virus replication and involves PRRs in a cell-type-dependent manner. While nonimmune cells relied entirely on recognition of dsRNA through RIG-I for activation of an antiviral response, myeloid cells utilized both the single-stranded RNA sensing TLR7 and TLR8 and dsRNA-dependent mechanisms independent of RIG-I, TLR3, and dsRNA-activated protein kinase R to trigger this response. Therefore, there appears to be a large degree of cell-type specificity in the mechanisms used by the host to recognize infecting viruses.

Authors/Editors

- Uni.-Prof. Dr. Friedemann Johannes Weber

Citation Styles

Harvard Citation style: Melchjorsen, J., Jensen, S., Malmgaard, L., Rasmussen, S., Weber, F., Bowie, A., et al. (2005) Activation of Innate Defense against a Paramyxovirus Is Mediated by RIG-I and TLR7 and TLR8 in a Cell-Type-Specific Manner, Journal of Virology, 79(20), pp. 12944-12951. https://doi.org/10.1128/JVI.79.20.12944-12951.2005

APA Citation style: Melchjorsen, J., Jensen, S., Malmgaard, L., Rasmussen, S., Weber, F., Bowie, A., Matikainen, S., & Paludan, S. (2005). Activation of Innate Defense against a Paramyxovirus Is Mediated by RIG-I and TLR7 and TLR8 in a Cell-Type-Specific Manner. Journal of Virology. 79(20), 12944-12951. https://doi.org/10.1128/JVI.79.20.12944-12951.2005