Journal article

Authors list: Zakrzewicz, D; Geyer, J

Publication year: 2023

Pages: 673-690

Journal: Biological Chemistry

Volume number: 404

Issue number: 7

ISSN: 1431-6730

eISSN: 1437-4315

Open access status: Hybrid

DOI Link: https://doi.org/10.1515/hsz-2022-0345

Publisher: De Gruyter Brill

Abstract: 
Na+/taurocholate cotransporting polypeptide (NTCP) is a member of the solute carrier (SLC) family 10 transporters (gene symbol SLC10A1) and is responsible for the sodium-dependent uptake of bile salts across the basolateral membrane of hepatocytes. In addition to its primary transporter function, NTCP is the high-affinity hepatic receptor for hepatitis B (HBV) and hepatitis D (HDV) viruses and, therefore, is a prerequisite for HBV/HDV virus entry into hepatocytes. The inhibition of HBV/HDV binding to NTCP and internalization of the virus/NTCP receptor complex has become a major concept in the development of new antiviral drugs called HBV/HDV entry inhibitors. Hence, NTCP has emerged as a promising target for therapeutic interventions against HBV/HDV infections in the last decade. In this review, recent findings on protein-protein interactions (PPIs) between NTCP and cofactors relevant for entry of the virus/NTCP receptor complex are summarized. In addition, strategies aiming to block PPIs with NTCP to dampen virus tropism and HBV/HDV infection rates are discussed. Finally, this article suggests novel directions for future investigations evaluating the functional contribution of NTCP-mediated PPIs in the development and progression of HBV/HDV infection and subsequent chronic liver disorders.

Harvard Citation style: Zakrzewicz, D. and Geyer, J. (2023) Interactions of Na+/taurocholate cotransporting polypeptide with host cellular proteins upon hepatitis B and D virus infection: novel potential targets for antiviral therapy, Biological Chemistry, 404(7), pp. 673-690. https://doi.org/10.1515/hsz-2022-0345

APA Citation style: Zakrzewicz, D., & Geyer, J. (2023). Interactions of Na+/taurocholate cotransporting polypeptide with host cellular proteins upon hepatitis B and D virus infection: novel potential targets for antiviral therapy. Biological Chemistry. 404(7), 673-690. https://doi.org/10.1515/hsz-2022-0345