Journalartikel

Autorenliste: Pichlmair, A; Schulz, O; Tan, CP; Näslund, TI; Liljeström, P; Weber, F; Sousa, CRE

Jahr der Veröffentlichung: 2006

Seiten: 997-1001

Zeitschrift: Science

Bandnummer: 314

Heftnummer: 5801

ISSN: 0036-8075

eISSN: 1095-9203

DOI Link: https://doi.org/10.1126/science.1132998

Verlag: American Association for the Advancement of Science

Abstract: 
Double-stranded RNA ( dsRNA) produced during viral replication is believed to be the critical trigger for activation of antiviral immunity mediated by the RNA helicase enzymes retinoic acid inducible gene I (RIG-I) and melanoma differentiation - associated gene 5 (MDA5). We showed that influenza A virus infection does not generate dsRNA and that RIG-I is activated by viral genomic single-stranded RNA (ssRNA) bearing 5'-phosphates. This is blocked by the influenza protein nonstructured protein 1 (NS1), which is found in a complex with RIG-I in infected cells. These results identify RIG-I as a ssRNA sensor and potential target of viral immune evasion and suggest that its ability to sense 5'-phosphorylated RNA evolved in the innate immune system as a means of discriminating between self and nonself.

Harvard-Zitierstil: Pichlmair, A., Schulz, O., Tan, C., Näslund, T., Liljeström, P., Weber, F., et al. (2006) RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-Phosphates, Science, 314(5801), pp. 997-1001. https://doi.org/10.1126/science.1132998

APA-Zitierstil: Pichlmair, A., Schulz, O., Tan, C., Näslund, T., Liljeström, P., Weber, F., & Sousa, C. (2006). RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-Phosphates. Science. 314(5801), 997-1001. https://doi.org/10.1126/science.1132998