Journal article

Authors list: Weber, F; Haller, O

Publication year: 2007

Pages: 836-842

Journal: Biochimie

Volume number: 89

Issue number: 6-7

ISSN: 0300-9084

eISSN: 1638-6183

DOI Link: https://doi.org/10.1016/j.biochi.2007.01.005

Publisher: Elsevier

Abstract: 

Type I interferons (IFN-alpha/beta) were originally discovered by their strong and direct antiviral activity [A. Isaacs, J. Lindenmann, Virus interference. I. The interferon, Proc. R. Soc. Lond. B Biol. Sci. 147 (1957) 258-267]. (see review by J. Lindenmann on p. 719, in this issue). Nevertheless, only very recently it was entirely realized that viruses would not succeed without efficient tools to undermine this potent host defense system. Current investigations are revealing an astonishing variety of viral IFN antagonistic strategies targeting virtually all parts of the IFN system, often in a highly specific manner. Viruses were found to interfere with induction of IFN synthesis, IFN-induced signaling events, the antiviral effector proteins, or simply shut off the host cell macromolecule synthesis machinery to avoid booting of the antiviral host defense. Here, we will describe a few well-characterized examples to illustrate the sophisticated and often multi-layered anti-IFN mechanisms employed by viruses.

Harvard Citation style: Weber, F. and Haller, O. (2007) Viral suppression of the interferon system, Biochimie, 89(6-7), pp. 836-842. https://doi.org/10.1016/j.biochi.2007.01.005

APA Citation style: Weber, F., & Haller, O. (2007). Viral suppression of the interferon system. Biochimie. 89(6-7), 836-842. https://doi.org/10.1016/j.biochi.2007.01.005