Journal article

Authors list: Cervantes-Barragan, L; Züst, R; Weber, F; Spiegel, M; Lang, KS; Akira, S; Thiel, V; Ludewig, B

Publication year: 2007

Pages: 1131-1137

Journal: Blood

Volume number: 109

Issue number: 3

ISSN: 0006-4971

DOI Link: https://doi.org/10.1182/blood-2006-05-023770

Publisher: American Society of Hematology (ASH Publications)

Abstract: 
This study demonstrates a unique and crucial role of plasmacytold dendritic cells (pDCs) and pDC-derived type I interferons (IFNs) in the pathogenesis of mouse coronavirus infection. pDCs controlled the fast replicating mouse hepatitis virus (MHV) through the immediate production of type I IFNs. Recognition of MHV by pDCs was mediated via TLR7 ensuring a swift IFN-alpha production following encounter with this cytopathic RNA virus. Furthermore, the particular type I IFN response pattern was not restricted to the murine coronavirus, but was also found in infection with the highly cytopathic human severe acute respiratory syndrome (SARS) coronavirus. Taken together, our results suggest that rapid production of type I IFNs by pDCs is essential for the control of potentially lethal coronavirus infections.

Harvard Citation style: Cervantes-Barragan, L., Züst, R., Weber, F., Spiegel, M., Lang, K., Akira, S., et al. (2007) Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon, Blood, 109(3), pp. 1131-1137. https://doi.org/10.1182/blood-2006-05-023770

APA Citation style: Cervantes-Barragan, L., Züst, R., Weber, F., Spiegel, M., Lang, K., Akira, S., Thiel, V., & Ludewig, B. (2007). Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon. Blood. 109(3), 1131-1137. https://doi.org/10.1182/blood-2006-05-023770