Journal article

Authors list: Andersson, I; Karlberg, H; Mousavi-Jazi, M; Martínez-Sobrido, L; Weber, F; Mirazimi, A

Publication year: 2008

Pages: 1397-1404

Journal: Journal of Medical Virology

Volume number: 80

Issue number: 8

ISSN: 0146-6615

DOI Link: https://doi.org/10.1002/jmv.21222

Publisher: Wiley

Abstract: 
As a first line of defence against virus infection, mammalian cells elicit an innate immune response, characterized by secretion of type I interferons and the up-regulation of interferon stimulated genes. Many viruses down-regulate the innate immune responses in order to enhance their virulence. Crimean-Congo hemorrhagic fever virus (CCHFV), a Nairovirus of the family Bunyaviridae is the causative agent of severe hemorrhagic fever in humans with high mortality. Knowledge regarding the innate immune response against CCHFV is most limited. Interestingly, in this study it is shown that replicating CCHFV delays substantially the IFN response, possibly by interfering with the activation pathway of IRF-3. In addition, it is demonstrated that CCHFV replication is almost insensitive to subsequent treatment with interferon-alpha. Once the virus is replicating, virus replication is more or less insensitive to the antiviral effects induced by the interferon. By using an interferon bioassay, it is shown that infected cells secrete interferon relatively late after infection, that is, 48 hr post-infection. In summary, the results suggest the presence of a virulence factor encoded by CCHFV that delays the host defence in order to allow rapid viral spread in the host.

Harvard Citation style: Andersson, I., Karlberg, H., Mousavi-Jazi, M., Martínez-Sobrido, L., Weber, F. and Mirazimi, A. (2008) Crimean-Congo hemorrhagic fever virus delays activation of the innate immune response, Journal of Medical Virology, 80(8), pp. 1397-1404. https://doi.org/10.1002/jmv.21222

APA Citation style: Andersson, I., Karlberg, H., Mousavi-Jazi, M., Martínez-Sobrido, L., Weber, F., & Mirazimi, A. (2008). Crimean-Congo hemorrhagic fever virus delays activation of the innate immune response. Journal of Medical Virology. 80(8), 1397-1404. https://doi.org/10.1002/jmv.21222