Journal article

Authors list: Pichlmair, A; Habjan, M; Unger, H; Weber, F

Publication year: 2010

Pages: 701-703

Journal: Vector-Borne and Zoonotic Diseases

Volume number: 10

Issue number: 7

ISSN: 1530-3667

eISSN: 1557-7759

DOI Link: https://doi.org/10.1089/vbz.2009.0248

Publisher: Mary Ann Liebert

Abstract: 

Rift Valley fever virus (RVFV), a member of the family Bunyaviridae, regularly accounts for large and severe outbreaks among humans and livestock in Africa and Arabia. Therefore, safe and efficient vaccines are highly needed. Here, we report the production of recombinant virus-like particles (VLPs) that, in addition to their similarity to RVFV particles, are able to express the viral nucleocapsid (N) gene. A single inoculation of 1 × 10⁶ of these N-VLPs was sufficient to protect 100% of mice from infection with a lethal dose of 1 × 10⁵ PFU of RVFV. Our study demonstrates that N-VLPs can be considered as a safe and efficient vaccine against the emerging pathogen RVFV, and that VLPs that actively produce a viral antigen may be considered a strategy to improve the immunogenicity of VLPs in general.

Harvard Citation style: Pichlmair, A., Habjan, M., Unger, H. and Weber, F. (2010) Virus-Like Particles Expressing the Nucleocapsid Gene as an Efficient Vaccine Against Rift Valley Fever Virus, Vector-Borne and Zoonotic Diseases, 10(7), pp. 701-703. https://doi.org/10.1089/vbz.2009.0248

APA Citation style: Pichlmair, A., Habjan, M., Unger, H., & Weber, F. (2010). Virus-Like Particles Expressing the Nucleocapsid Gene as an Efficient Vaccine Against Rift Valley Fever Virus. Vector-Borne and Zoonotic Diseases. 10(7), 701-703. https://doi.org/10.1089/vbz.2009.0248