Journal article

Authors list: Kristiansen, H; Scherer, CA; McVean, M; Iadonato, SP; Vends, S; Thavachelvam, K; Steffensen, TB; Horan, KA; Kuri, T; Weber, F; Paludan, SR; Hartmann, R

Publication year: 2010

Pages: 11898-11904

Journal: Journal of Virology

Volume number: 84

Issue number: 22

ISSN: 0022-538X

eISSN: 1098-5514

DOI Link: https://doi.org/10.1128/JVI.01003-10

Publisher: American Society for Microbiology

Abstract: 

The 2′-5′ oligoadenylate synthetase (OAS) proteins are traditionally considered intracellular antiviral proteins. However, several studies demonstrate a correlation between the concentration of freely circulating OAS protein in sera from hepatitis C patients and their clinical prognosis. Here we demonstrate that extracellular OAS1 enters into cells and possesses a strong antiviral activity, both in vitro and in vivo, which is independent of RNase L. The OAS protein directly inhibits viral proliferation and does not require the activation of known antiviral signaling pathways. We propose that OAS produced by cells infected with viruses is released to the extracellular space, where it acts as a paracrine antiviral agent. Thus, the OAS protein represents the first direct antiviral compound released by virus-infected cells.

Harvard Citation style: Kristiansen, H., Scherer, C., McVean, M., Iadonato, S., Vends, S., Thavachelvam, K., et al. (2010) Extracellular 2′-5′ Oligoadenylate Synthetase Stimulates RNase L-Independent Antiviral Activity: a Novel Mechanism of Virus-Induced Innate Immunity, Journal of Virology, 84(22), pp. 11898-11904. https://doi.org/10.1128/JVI.01003-10

APA Citation style: Kristiansen, H., Scherer, C., McVean, M., Iadonato, S., Vends, S., Thavachelvam, K., Steffensen, T., Horan, K., Kuri, T., Weber, F., Paludan, S., & Hartmann, R. (2010). Extracellular 2′-5′ Oligoadenylate Synthetase Stimulates RNase L-Independent Antiviral Activity: a Novel Mechanism of Virus-Induced Innate Immunity. Journal of Virology. 84(22), 11898-11904. https://doi.org/10.1128/JVI.01003-10