Journalartikel

Autorenliste: Kuri, T; Eriksson, KK; Putics, A; Züst, R; Snijder, EJ; Davidson, AD; Siddell, SG; Thiel, V; Ziebuhr, J; Weber, F

Jahr der Veröffentlichung: 2011

Seiten: 1899-1905

Zeitschrift: Journal of General Virology

Bandnummer: 92

Heftnummer: 8

ISSN: 0022-1317

eISSN: 1465-2099

DOI Link: https://doi.org/10.1099/vir.0.031856-0

Verlag: Microbiology Society

Abstract: 

Several plus-strand RNA viruses encode proteins containing macrodomains. These domains possess ADP-ribose-1″-phosphatase (ADRP) activity and/or bind poly(ADP-ribose), poly(A) or poly(G). The relevance of these activities in the viral life cycle has not yet been resolved. Here, we report that genetically engineered mutants of severe acute respiratory syndrome coronavirus (SARS-CoV) and human coronavirus 229E (HCoV-229E) expressing ADRP-deficient macrodomains displayed an increased sensitivity to the antiviral effect of alpha interferon compared with their wild-type counterparts. The data suggest that macrodomain-associated ADRP activities may have a role in viral escape from the innate immune responses of the host.

Harvard-Zitierstil: Kuri, T., Eriksson, K., Putics, A., Züst, R., Snijder, E., Davidson, A., et al. (2011) The ADP-ribose-1″-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses, Journal of General Virology, 92(8), pp. 1899-1905. https://doi.org/10.1099/vir.0.031856-0

APA-Zitierstil: Kuri, T., Eriksson, K., Putics, A., Züst, R., Snijder, E., Davidson, A., Siddell, S., Thiel, V., Ziebuhr, J., & Weber, F. (2011). The ADP-ribose-1″-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses. Journal of General Virology. 92(8), 1899-1905. https://doi.org/10.1099/vir.0.031856-0