Journal article

Authors list: Mooren, FC; Krüger, K; Ringseis, R; Eder, K; Liebisch, G; Conrad, K; Alack, K; Maleki, BH

Publication year: 2020

Pages: R1103-R1115

Journal: American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

Volume number: 318

Issue number: 6

ISSN: 0363-6119

eISSN: 1522-1490

Open access status: Bronze

DOI Link: https://doi.org/10.1152/ajpregu.00341.2019

Publisher: American Physiological Society

Abstract: 

This study aimed to investigate the effects of a short-term (36 h) fasting period combined with an acute bout of exercise on markers of immune function and inflammation in healthy human subjects. Fourteen moderately trained male subjects (aged 19-39 yr) participated in a 36-h fasting trial (FA-T), followed by an acute bout of moderate exercise (60% (V) over dot (O2max)). After 1 wk. the same subjects, as their own control, participated in a non fasting trial (NFA-T) in which they performed an exercise trial of the same duration and intensity. Blood samples were taken before, immediately after, and 1 h after each exercise bout and analyzed for several immunological and metabolic markers. At baseline, fasting subjects showed lower levels of T cell apoptosis, lymphocyte-proliferative responses. IL-6, monocyte chemoattractant protein-1 (MCP-1), insulin, and leptin (P < 0.05) as well as higher levels of neutrophil oxidative burst and thiobarbituric acid reactive substances (TBARS) than those in the NFA-T (P < 0.05). After the exercise protocol, fasted subjects revealed higher T cell apoptosis. neutrophil oxidative burst. TBARS, TNF alpha, and MCP-1 levels as well as lower levels of lymphocyte-proliferative response, IL-6, insulin, and leptin than those in the NFA-T (P < 0.05). Short-term fasting aggravates perturbations in markers of immune function, and inflammation was induced by an acute moderate-intensity exercise protocol.

Harvard Citation style: Mooren, F., Krüger, K., Ringseis, R., Eder, K., Liebisch, G., Conrad, K., et al. (2020) Combined effects of moderate exercise and short-term fasting on markers of immune function in healthy human subjects, American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 318(6), pp. R1103-R1115. https://doi.org/10.1152/ajpregu.00341.2019

APA Citation style: Mooren, F., Krüger, K., Ringseis, R., Eder, K., Liebisch, G., Conrad, K., Alack, K., & Maleki, B. (2020). Combined effects of moderate exercise and short-term fasting on markers of immune function in healthy human subjects. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology. 318(6), R1103-R1115. https://doi.org/10.1152/ajpregu.00341.2019