Journal article

Authors list: Kaiser, Anna; Schaefer, Sylva M.; Behrendt, Inken; Eichner, Gerrit; Fasshauer, Mathias

Publication year: 2023

Pages: 294-303

Journal: British Journal of Nutrition

Volume number: 130

Issue number: 2

ISSN: 0007-1145

eISSN: 1475-2662

Open access status: Hybrid

DOI Link: https://doi.org/10.1017/S0007114522003233

Publisher: Cambridge University Press

Abstract: 

The present study elucidates the association of intrinsic sugars and free sugars (FS) from all relevant sources with all-cause mortality in the prospective UK Biobank cohort. Sugar intake was assessed in 186 811 UK Biobank participants who completed at least one web-based 24-h dietary recall (Oxford WebQ). Cox proportional hazard regression models for all-cause mortality were used with sugar intake from different sources included as penalised cubic splines to allow non-linear predictor effects. Over a mean follow-up of 12·3 years, 8576 (4·6 %) deaths occurred. FS but not intrinsic sugars were significantly and dose-dependently associated with hazard ratio (HR) for all-cause mortality. The association with all-cause mortality was significant and dose dependent for FS in beverages, but not in solids with the mean (CI) HR at 50 g/d v. 0 g/d consumption at 1·10, 95 % CI (1·07, 1·14) and 1·01, 95 % CI (0·98, 1·03), respectively. Within the beverages subcategories, a significant dose-dependent association with mortality was detected for FS in soda/fruit drinks and milk-based drinks whereas this relation was NS for FS in pure juice and tea/coffee. FS in four different subtypes of solids, i.e. treats, cereals, toppings and sauces, were not positively associated with all-cause mortality. Major findings were robust in sensitivity analyses. In conclusion, only some FS sources were associated with all-cause mortality. Interventions targeting FS subtypes might be most effective concerning mortality if focused on the reduction of soda/fruit drinks and milk-based sugary drinks; however, the present results need to be confirmed by independent studies.

Harvard Citation style: Kaiser, A., Schaefer, S., Behrendt, I., Eichner, G. and Fasshauer, M. (2023) Association of all-cause mortality with sugar intake from different sources in the prospective cohort of UK Biobank participants, British Journal of Nutrition, 130(2), pp. 294-303. https://doi.org/10.1017/S0007114522003233

APA Citation style: Kaiser, A., Schaefer, S., Behrendt, I., Eichner, G., & Fasshauer, M. (2023). Association of all-cause mortality with sugar intake from different sources in the prospective cohort of UK Biobank participants. British Journal of Nutrition. 130(2), 294-303. https://doi.org/10.1017/S0007114522003233