Journalartikel

Autorenliste: Bill, Mona-K; Kleiner, Yolanda; Flügel, Jana L.; Kurz, Michael; Spohn, Marius; Marner, Michael; Mihajlovic, Sanja; Vilcinskas, Andreas; Schäberle, Till F.; Hammann, Peter E.; Patras, Maria A.; Schuler, Sören MM

Jahr der Veröffentlichung: 2022

Seiten: 576-582

Zeitschrift: Journal of Antibiotics

Bandnummer: 75

Heftnummer: 10

ISSN: 0021-8820

eISSN: 1881-1469

DOI Link: https://doi.org/10.1038/s41429-022-00557-z

Verlag: Springer Nature [academic journals on nature.com]

Abstract: 
Nine new hydroxyphenyloxazolines, madurastatin B4, C2, D3 and D4, E1 and E2, F1 as well as G1 and G2 (8-16), along with two new enantiomers of madurastatin D1 (ent-6) and D2 (ent-7) and two known congeners, madurastatin B1 (2) and C1 (5), were isolated from the liquid culture of Actinomadura sp. ST100801 based on the initial activity against Escherichia coli screened in bicarbonate-supplemented Mueller Hinton II medium and identification via molecular networking. Structure elucidation was achieved by comprehensive 1D and 2D NMR as well as MS/MS fragmentation analyses. Their absolute configuration was determined by Marfey's analysis. Complemented with functionalized hydroxyphenyloxazolines (2, 4, 17-18) obtained by total synthesis, the isolated compounds were evaluated for antibacterial activities revealing MICs down to 4 mu g ml(-1) against Moraxella catarrhalis. Therefore, this study enlarges the family of madurastatin siderophores.

Harvard-Zitierstil: Bill, M., Kleiner, Y., Flügel, J., Kurz, M., Spohn, M., Marner, M., et al. (2022) Isolation, characterization, and bioactivity profiling of oxazoline containing madurastatin siderophores from Actinomadura sp., Journal of Antibiotics, 75(10), pp. 576-582. https://doi.org/10.1038/s41429-022-00557-z

APA-Zitierstil: Bill, M., Kleiner, Y., Flügel, J., Kurz, M., Spohn, M., Marner, M., Mihajlovic, S., Vilcinskas, A., Schäberle, T., Hammann, P., Patras, M., & Schuler, S. (2022). Isolation, characterization, and bioactivity profiling of oxazoline containing madurastatin siderophores from Actinomadura sp.. Journal of Antibiotics. 75(10), 576-582. https://doi.org/10.1038/s41429-022-00557-z