Journalartikel

Autorenliste: EFSA FEZ Panel; Zorn, Holger; Barat Baviera, José Manuel; Bolognesi, Claudia; Catania, Francesco; Gadermaier, Gabriele; Greiner, Ralf; Mayo, Baltasar; Mortensen, Alicja; Roos, Yrjö Henrik; Solano, Marize de Lourdes Marzo; Sramkova, Monika; Van Loveren, Henk; Vernis, Laurence; Cavanna, Daniele; Fernàndez-Fraguas, Cristina; Liu, Yi; Marini, Eleonora

Jahr der Veröffentlichung: 2024

Zeitschrift: EFSA Journal

Bandnummer: 22

Heftnummer: 8

eISSN: 1831-4732

DOI Link: https://doi.org/10.2903/j.efsa.2024.8935

Verlag: Wiley

Abstract: 
The food enzyme glucan 1,4-alpha-maltohydrolase (4-alpha-d-glucan alpha-maltohydrolase; EC 3.2.1.133) is produced with the genetically modified Saccharomyces cerevisiae strain LALL-MA+ by Danstar Ferment AG. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism and its DNA. It is intended to be used in the processing of cereals and other grains for production of baked products. Dietary exposure was estimated to be up to 0.014 mg TOS/kg body weight per day in European populations. Given the QPS status of the production strain and the absence of concerns resulting from the food enzyme manufacturing process, toxicity tests were considered unnecessary by the Panel. A search for the identity of the amino acid sequence of the food enzyme to known allergens was made and four matches were found, three with respiratory allergens and one with an allergen from mosquito (injected). The Panel considered that the risk of allergic reactions upon dietary exposure cannot be excluded, but the likelihood is low. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns, under the intended conditions of use.

Harvard-Zitierstil: EFSA FEZ Panel, Zorn, H., Barat Baviera, J., Bolognesi, C., Catania, F., Gadermaier, G., et al. (2024) Safety evaluation of the food enzyme glucan 1,4-α-maltohydrolase from the genetically modified Saccharomyces cerevisiae strain LALL-MA+, EFSA Journal, 22(8), Article e8935. https://doi.org/10.2903/j.efsa.2024.8935

APA-Zitierstil: EFSA FEZ Panel, Zorn, H., Barat Baviera, J., Bolognesi, C., Catania, F., Gadermaier, G., Greiner, R., Mayo, B., Mortensen, A., Roos, Y., Solano, M., Sramkova, M., Van Loveren, H., Vernis, L., Cavanna, D., Fernàndez-Fraguas, C., Liu, Y., & Marini, E. (2024). Safety evaluation of the food enzyme glucan 1,4-α-maltohydrolase from the genetically modified Saccharomyces cerevisiae strain LALL-MA+. EFSA Journal. 22(8), Article e8935. https://doi.org/10.2903/j.efsa.2024.8935