Journal article

Authors list: Neuser, F; Zorn, H; Berger, RG

Publication year: 2000

Pages: 560-568

Journal: A Journal of Biosciences

Volume number: 55

Issue number: 7-8

ISSN: 0939-5075

DOI Link: https://doi.org/10.1515/znc-2000-7-814

Publisher: De Gruyter

Abstract: 
The wild-type yeast strain Zygosaccharomyces bisporus CBS 702 produced alpha-hydroxyketones (acyloins) from amino acid precursors after transamination to the corresponding 2-oxo acids. The key enzyme of the subsequent decarboxylation and C-C bond forming reaction, pyruvate decarboxylase (PDC), was examined for its substrate- and stereo-specificity. A wide variety of saturated and unsaturated aliphatic and aromatic aldehydes was successfully converted to acyloins. 19 of the biotransformation products identified had not been reported as natural substances before. Product yields were strongly affected by substrate structure.

Harvard Citation style: Neuser, F., Zorn, H. and Berger, R. (2000) Formation of aliphatic and aromatic α-hydroxy ketones by Zygosaccharomyces bisporus, Zeitschrift fur Naturforschung C, 55(7-8), pp. 560-568. https://doi.org/10.1515/znc-2000-7-814

APA Citation style: Neuser, F., Zorn, H., & Berger, R. (2000). Formation of aliphatic and aromatic α-hydroxy ketones by Zygosaccharomyces bisporus. Zeitschrift fur Naturforschung C. 55(7-8), 560-568. https://doi.org/10.1515/znc-2000-7-814