Journal article

Authors list: Thiel, V; Weber, F

Publication year: 2008

Pages: 121-132

Journal: Cytokine & Growth Factor Reviews

Volume number: 19

Issue number: 2

ISSN: 1359-6101

eISSN: 1879-0305

DOI Link: https://doi.org/10.1016/j.cytogfr.2008.01.001

Publisher: Elsevier

Abstract: 

The sudden emergence of severe acute respiratory syndrome (SARS) has boosted research on innate immune responses to coronaviruses. It is now well established that the causative agent, a newly identified coronavirus termed SARS-CoV, employs multiple passive and active mechanisms to avoid induction of the antiviral type I interferons in tissue cells. By contrast, chemokines such as IP-10 or IL-8 are strongly upregulated. The imbalance in the IFN response is thought to contribute to the establishment of viremia early in infection, whereas the production of chemokines by infected organs may be responsible for (i) massive immune cell infiltrations found in the lungs of SARS victims, and (ii) the dysregulation of adaptive immunity. Here, we will review the most recent findings on the interaction of SARS-CoV and related Coronaviridae members with the type I interferon and cytokine responses and discuss implications for pathogenesis and therapy.

Harvard Citation style: Thiel, V. and Weber, F. (2008) Interferon and cytokine responses to SARS-coronavirus infection, Cytokine & Growth Factor Reviews, 19(2), pp. 121-132. https://doi.org/10.1016/j.cytogfr.2008.01.001

APA Citation style: Thiel, V., & Weber, F. (2008). Interferon and cytokine responses to SARS-coronavirus infection. Cytokine & Growth Factor Reviews. 19(2), 121-132. https://doi.org/10.1016/j.cytogfr.2008.01.001